The New Kids on the (NAA) Block, aka the Early Investigator Committee, are excited to share that the inaugural virtual symposium series was a great success! We welcomed 115 attendees for…

In memory of Professor Michael O’Rourke and Professor Michel Safar who each passed away recently….

Across our society, we’ve been hard at work to bring you new programming, new ideas, and new awards at a new location while honoring our fundamental roots in arterial function. While I won’t spoil all the fun yet, I can guarantee you that you won’t want to miss all that we have planned in 2024 starting with the highlights…

The North American Artery Society was proud to participate in the ASN Kidney Week Conference on November 2-5, 2023 in Philadelphia, Pennsylvania.

Cellular senescence is a fundamental hallmark of aging biology; however, its role in mediating age-related vascular dysfunction was unknown. Here, we show that cellular senescence directly contributes to age-related aortic stiffness and vascular endothelial dysfunction. Moreover, we demonstrate the efficacy of senolytic (senescent cell clearing) therapy for reversing aortic stiffness and endothelial dysfunction in old animals.

Much of the preclinical vascular aging work in mice has been conducted in male animals, which ultimately limits the translational potential of the findings. Here, we demonstrate that old female C57BL/6N mice accurately reflect age-related aortic stiffening in women, and therefore are a viable model for studying vascular aging in older adult women.

Early-life exposure to high blood pressure (BP) is associated with cardiovascular target organ damage but not all BP-related risk is attributable to systolic and diastolic BP alone. In adolescence, aortic wave separation (WS) parameters are associated with increased left ventricular mass index (LVMI) but this approach is limited by the requirement for aortic flow measurements.

Hypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)-related increased arterial stiffness is present in youth with elevated BP and is associated with TOD.

Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic, and skeletal muscles may affect glucose homeostasis. Our goal was to evaluate the association between LAS and the risk of type 2 diabetes using prospectively collected, carefully phenotyped measurements of LAS as well as Mendelian randomization analyses.

Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically <10 years). Data regarding associations of arterial stiffness with health outcomes on longer-term follow-up are lacking.